Article

Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays

2022-07-13

Abstract excerpt

The radiation of mammals at the extinction of the dinosaurs produced a plethora of new forms—as diverse as bats, dolphins, and elephants—in only 10-20 million years. Behind the scenes, adaptation to new niches is accompanied by extensive innovation in large families of genes that allow animals to contact the environment, including chemosensors, xenobiotic enzymes, and immune and barrier proteins. Genes in these “o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98600727-1fd0-5734-959a-9366251d4250
DOI: 10.1101/2022.07.13.499775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arraysDOI 10.1101/2022.07.13.499775Read

Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays.Semantic proximity Read

Distinct evolutionary signatures shape depletion and conservation of short tandem repeat motifs in the human genome: insights into beta‑cell function and diabetesSemantic proximity Read

Vanishing GC-rich isochores in mammalian genomes.Semantic proximity Read

Evolutionary constraint and innovation across hundreds of placental mammalsSemantic proximity Read

Accelerated Evolution in Distinctive Species Reveals Candidate Elements for Clinically Relevant Traits, Including Mutation and Cancer Resistance.Semantic proximity Read

Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots.Semantic proximity Read

Gene expression, synteny, and local similarity in human noncoding mutation rates.Semantic proximity Read

The GC-content at the 5' ends of human protein-coding genes is undergoing mutational decay.Semantic proximity Read

Interpreting mammalian evolutionary constraint at synonymous sites in light of the unwanted transcript hypothesisSemantic proximity Read

CpG island turnover events predict evolutionary changes in enhancer activitySemantic proximity Read

The GC-content at the 5’ends of human protein-coding genes is undergoing mutational decaySemantic proximity Read

Drosophila functional elements are embedded in structurally constrained sequences.Semantic proximity Read