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Article

The GC-content at the 5' ends of human protein-coding genes is undergoing mutational decay.

Genome biology - 13 Aug 2024

Qiu Yi, Kang Yoon Mo, Korfmann Christopher, Pouyet Fanny, Eckford Andrew, Palazzo Alexander F

Abstract excerpt

BACKGROUND: In vertebrates, most protein-coding genes have a peak of GC-content near their 5' transcriptional start site (TSS). This feature promotes both the efficient nuclear export and translation of mRNAs. Despite the importance of GC-content for RNA metabolism, its general features, origin, and maintenance remain mysterious. We investigate the evolutionary forces shaping GC-content at the transcriptional...

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PMID: 39138526
DOI: 10.1186/s13059-024-03364-x
PMCID: PMC11323403

Genes

GC
PRDM9

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