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Article

Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots.

Genome biology and evolution - 1 Jan 2011

Katzman Sol, Capra John A, Haussler David, Pollard Katherine S

Abstract excerpt

Fast evolving regions of many metazoan genomes show a bias toward substitutions that change weak (A,T) into strong (G,C) base pairs. Single-nucleotide polymorphisms (SNPs) do not share this pattern, suggesting that it results from biased fixation rather than biased mutation. Supporting this hypothesis, analyses of polymorphism in specific regions of the human genome have identified a positive correlation between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21697099
DOI: 10.1093/gbe/evr058
PMCID: PMC3157837

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