Article

Distinct evolutionary signatures shape depletion and conservation of short tandem repeat motifs in the human genome: insights into beta‑cell function and diabetes

2026-07-20

Abstract excerpt

<title>Abstract</title> <p>Short tandem repeats (STRs) are abundant components of the genome that contribute to genetic variation and genome instability and have been implicated in numerous human diseases, particularly neurological disorders. Although STR instability has been extensively characterized at individual loci, the broader evolutionary forces shaping STR sequence distributions across the genome remain i...

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Literature Corpus work: b5ef40c1-455a-5108-a943-c2719aa0f679
DOI: 10.21203/rs.3.rs-10388048/v1

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