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SAMPDI-3D: predicting the effects of protein and DNA mutations on protein-DNA interactions.

Bioinformatics (Oxford, England) - 5 Nov 2021

Li Gen, Panday Shailesh Kumar, Peng Yunhui, Alexov Emil

Abstract excerpt

MOTIVATION: Mutations that alter protein-DNA interactions may be pathogenic and cause diseases. Therefore, it is extremely important to quantify the effect of mutations on protein-DNA binding free energy to reveal the molecular origin of diseases and to assist the development of treatments. Although several methods that predict the change of protein-DNA binding affinity upon mutations in the binding protein were...

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PMID: 34343273
DOI: 10.1093/bioinformatics/btab567
PMCID: PMC10186157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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