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DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein-protein complexes upon mutation.

Bioinformatics (Oxford, England) - 2 May 2024

Nikam Rahul, Jemimah Sherlyn, Gromiha M Michael

Abstract excerpt

MOTIVATION: Protein-protein interactions underpin many cellular processes and their disruption due to mutations can lead to diseases. With the evolution of protein structure prediction methods like AlphaFold2 and the availability of extensive experimental affinity data, there is a pressing need for updated computational tools that can efficiently predict changes in binding affinity caused by mutations in...

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PMID: 38718170
DOI: 10.1093/bioinformatics/btae309
PMCID: PMC11112046

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