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PDA-MutPred: Reliable prediction of binding affinity change upon mutation in protein-DNA complexes.

International journal of biological macromolecules - 1 Aug 2026

Harini K, Yasuo N, Sekijima M, Gromiha M Michael

Abstract excerpt

Mutations in protein-DNA complexes interfere with normal cell functions by causing structural changes, leading to the dissociation of complexes or altering the affinity of interactions between proteins and DNA. Reliable prediction of binding affinity changes (ΔΔG) upon amino acid mutation in protein-DNA complexes in a challenging problem in computational biology. In this work, we compiled a set of 1169 mutations...

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PMID: 42349588
DOI: 10.1016/j.ijbiomac.2026.153205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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