Article

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer

2025-06-07

Abstract excerpt

<h4>ABSTRACT</h4> LIMD1 (LIM domains containing 1) is a bona-fide tumour suppressor gene frequently lost during the early stages of non-small cell lung cancer (NSCLC) development, resulting in a worse outcome for LIMD1 -deficient patients. LIMD1 deficiency is present in approximately 50% of NSCLC cases, representing at least 21,000 patients in the United Kingdom and 1.2 million worldwide. During cancer progress...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9840b67d-ab5c-50df-aac9-dd479a5076d6
DOI: 10.1101/2025.06.06.658274

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung CancerDOI 10.1101/2025.06.06.658274Read

Targeted therapy for <i>LIMD1</i> -deficient non-small cell lung cancer subtypesSemantic proximity Read

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung CancerSemantic proximity Read

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung CancerSemantic proximity Read

Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathwaySemantic proximity Read

In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancerSemantic proximity Read

LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage diseaseSemantic proximity Read

KDM6B Inhibition Enhances Chemotherapeutic Response in Small Cell Lung Cancer via Epigenetic Regulation of Apoptosis and FerroptosisSemantic proximity Read

Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-MycSemantic proximity Read

NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathwaysSemantic proximity Read

Targeting FSP1 triggers ferroptosis in lung cancerSemantic proximity Read

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial DysfunctionSemantic proximity Read

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.Semantic proximity Read