Article

Targeted therapy for <i>LIMD1</i> -deficient non-small cell lung cancer subtypes

2021-02-02

Abstract excerpt

An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumourigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) are deficient in LIMD1 1 , yet this subtype of NSCLC has been overlooked in preclinical and clinical investigations. Defining therapeutic targets in...

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Literature Corpus work: 60c07e20-dcb5-58bb-b5de-5c8c2cdeaefb
DOI: 10.1101/2021.02.01.429178

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