Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction

1 Feb 2021

Abstract excerpt

CISD2, a NEET protein that coordinates 2Fe-2S clusters through its CDGSH domain, is critical for normal development and iron homeostasis. CISD2 plays an important role in Fe-S cluster transfer and promotes cancer proliferation. However, its specific role in the development of non-small cell lung cancer (NSCLC) remains unclear. Bioinformatics of pan-cancer analysis from The Cancer Genome Atlas show that CISD2 has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Metalloenzymes and iron-sulfur proteins
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33598426
DOI: 10.3389/fonc.2020.595524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial DysfunctionPMID 33598426Read ↗

Multi‐omics analysis reveals that ferroptosis‐related gene CISD2 is a prognostic biomarker of head and neck squamous cell carcinomaSemantic proximity Read ↗

Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic responseSemantic proximity Read ↗

CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449aSemantic proximity Read ↗

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung CancerSemantic proximity Read ↗

CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axisSemantic proximity Read ↗

SUSD2 down-regulation is correlated with the occurrence and development of lung cancerSemantic proximity Read ↗

Machine-learning developed an iron, copper, and sulfur-metabolism associated signature predicts lung adenocarcinoma prognosis and therapy responseSemantic proximity Read ↗

KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4Semantic proximity Read ↗

Inhibiting LCN2 can suppress the development of NSCLC by promoting ferroptosisSemantic proximity Read ↗

ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modificationSemantic proximity Read ↗

Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-MycSemantic proximity Read ↗

Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.