Article

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer

2025-03-31

Abstract excerpt

<title>Abstract</title> <p>LIMD1 is a tumour suppressor gene frequently lost in non-small cell lung cancer (NSCLC), but its role in cancer-immune cell interactions remains unexplored. Here, we demonstrate that LIMD1 loss results in upregulation of the key immune checkpoint protein PD-L1. Using multi-region sequencing from the TRACERx dataset, we identify that LIMD1 loss is clonal in over 80% of squamous cell carc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c46c397-f8e8-5002-928d-5a7f7aecede8
DOI: 10.21203/rs.3.rs-5975806/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung CancerDOI 10.21203/rs.3.rs-5975806/v1Read

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung CancerSemantic proximity Read

PD-L1 Expression in NSCLC: Clouds in a Bright SkySemantic proximity Read

Mutation mapping of PD-L1 expression in advanced non-small cell lung cancer: A real-world retrospective cohort studySemantic proximity Read

Targeted therapy for <i>LIMD1</i> -deficient non-small cell lung cancer subtypesSemantic proximity Read

Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas.Semantic proximity Read

Current Immunotherapeutic Strategies Targeting the PD-1/PD-L1 Axis in Non-Small Cell Lung Cancer with Oncogenic Driver Mutations.Semantic proximity Read

PD ‐ L1 and PD ‐ L2 expression correlated genes in non‐small‐cell lung cancerSemantic proximity Read

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung CancerSemantic proximity Read

Comprehensive assessment of PD-L1 expression, tumor mutational burden and oncogenic driver alterations in non-small cell lung cancer patients treated with immune checkpoint inhibitorsSemantic proximity Read

A machining learning-based prognostic model integrating multi-omics defines LGMN as a lysosomal checkpoint on macrophages with co- expressed myeloid checkpoints TIM-3 and LILRB4 associated with immunotherapy resistance in NSCLCSemantic proximity Read

Blood immunomap for prediction of responses to aPD1 immunotherapy in metastatic non-small cell lung cancerSemantic proximity Read

Identifying the Role of NUDCD1 in Human Tumors from Clinical and Molecular MechanismsSemantic proximity Read