Article

Molecular insights on the mechanism of <i>α</i> <sub>1</sub> -antitrypsin condensate formation and maturation

2025-03-14

Abstract excerpt

The deficiency of α 1 -antitrypsin protein is a genetic disorder characterized by the accumulation of misfolded protein aggregates within hepatocytes, leading to liver dysfunction. In the lung, it is found in macrophages, bronchial and epithelial alveolar cells type 2, leading to pulmonary emphysema. Despite extensive research, the precise mechanism underlying the formation of α 1 -antitrypsin inclusion bodies r...

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Literature Corpus work: 0a0314c1-56a4-5972-be7d-4a2c7d8b4b67
DOI: 10.1101/2025.03.11.642656

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