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Article

CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability

3 Jun 2022

Abstract excerpt

CHCHD10 is an amyotrophic lateral sclerosis/frontotemporal dementia gene that encodes a mitochondrial protein whose precise function is unclear. Here we show that Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing protein 10 interacts with the Stomatin-Like Protein 2 and participates in the stability of the prohibitin complex in the inner mitochondrial membrane. By using patient fibroblasts and mouse models...

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PMID: 35656794
DOI: 10.1093/brain/awac197

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CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viabilityPMID 35656794Read ↗

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