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Article

Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models

22 Apr 2021

Abstract excerpt

Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and other Lewy body disorders. CHCHD2 is a bi-organellar mediator of oxidative phosphorylation, playing crucial roles in regulating electron flow in the mitochondrial electron transport chain and acting as a nuclear transcription factor for a cytochrome c...

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Identifiers

PMID: 33967741
DOI: 10.3389/fnagi.2021.660843

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