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Article

Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β.

The Journal of cell biology - 7 Mar 2022

Kors Suzan, Hacker Christian, Bolton Chloe, Maier Renate, Reimann Lena, Kitchener Emily J A, Warscheid Bettina, Costello Joseph L, Schrader Michael

Abstract excerpt

Peroxisomes and the endoplasmic reticulum (ER) cooperate in cellular lipid metabolism. They form membrane contacts through interaction of the peroxisomal membrane protein ACBD5 (acyl-coenzyme A-binding domain protein 5) and the ER-resident protein VAPB (vesicle-associated membrane protein-associated protein B). ACBD5 binds to the major sperm protein domain of VAPB via its FFAT-like (two phenylalanines [FF] in an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35019937
DOI: 10.1083/jcb.202003143
PMCID: PMC8759595

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