Article

New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms

2024-06-22

Abstract excerpt

Acyl-CoA binding domain-containing proteins (ACBDs) perform diverse but often uncharacterised functions linked to cellular lipid metabolism. Human ACBD4 and ACBD5 are closely related peroxisomal membrane proteins, involved in tethering of peroxisomes to the ER and capturing fatty acids for peroxisomal β-oxidation. ACBD5 deficiency causes neurological abnormalities including ataxia and white matter disease. Peroxis...

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Literature Corpus work: e454ae4b-4963-5ef8-82f0-026fc28e7c18
DOI: 10.1101/2024.06.21.599987

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