Palmitoylation determines the function of Vac8 at the yeast vacuole.

doi:10.1242/jcs.02972

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Article

Palmitoylation determines the function of Vac8 at the yeast vacuole.

Journal of cell science - 15 Jun 2006

Subramanian Kanagaraj, Dietrich Lars E P, Hou Haitong, LaGrassa Tracy J, Meiringer Christoph T A, Ungermann Christian

Abstract excerpt

Palmitoylation stably anchors specific proteins to membranes, but may also have a direct effect on the function of a protein. The yeast protein Vac8 is required for efficient vacuole fusion, inheritance and cytosol-to-vacuole trafficking. It is anchored to vacuoles by an N-terminal myristoylation site and three palmitoylation sites, also known as the SH4 domain. Here, we address the role of Vac8 palmitoylation...

Topics

Cell Membrane
Cysteine
Lipoproteins
Membrane Proteins
Mutation
Palmitic Acid
Protein Processing, Post-Translational
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Vacuoles
Vesicular Transport Proteins
src Homology Domains

Source

Open in PubMed

Identifiers

PMID: 16720644
DOI: 10.1242/jcs.02972

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