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Article

Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation.

Scientific reports - 6 May 2020

Yamanaka Tomoyuki, Nishiyama Risa, Shimogori Tomomi, Nukina Nobuyuki

Abstract excerpt

An ER transmembrane protein, vesicle-associated membrane protein-associated protein B (VAPB), binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutation in amyotrophic lateral sclerosis (ALS) induces protein misfolding and aggregation, leading to ER disorganization. Gain or loss of function is suggested for VAPB mutation, however comprehensive study focusing on VAPB-ER...

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Identifiers

PMID: 32376919
DOI: 10.1038/s41598-020-64517-z
PMCID: PMC7203144

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