Article

Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors

2019-09-18

Abstract excerpt

<h4>Objectives</h4> The success of B cell depletion therapy in rheumatoid arthritis (RA) therapy testifies to their importance in disease pathogenesis, but the precise B cells mediating this are unclear. For example, it is unknown if RA patients predominantly express a limited number of circulating clonally expanded populations of B cells with highly mutated B cell antigen receptors (BCRs) that would constitute a...

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Literature Corpus work: 7878ec93-4310-53d3-86fe-a8cb9a7d1cc1
DOI: 10.1101/771949

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