Article

Fexinidazole induced cytotoxicity is distinct from related anti-trypanosome nitroaromatic drugs

2023-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Nitroaromatic drugs are of critical importance for the treatment of trypanosome infections in Africa and the Americas. Fexinidazole recently joined benznidazole and nifurtimox in this family when it was approved as the first oral therapy against Human African trypanosomiasis (HAT). Nitroaromatic prodrugs are bioactivated by the trypanosome-specific type I nitroreductase (NTR) enzyme that renders...

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Literature Corpus work: 980205f8-1ea0-57d8-bad9-d452ba847023
DOI: 10.1101/2023.10.09.561529

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