Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.

doi:10.1128/AAC.47.10.3368-3370.2003

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Article

Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.

Antimicrobial agents and chemotherapy - 1 Oct 2003

Enanga Bertin, Ariyanayagam Mark R, Stewart Mhairi L, Barrett Michael P

Abstract excerpt

DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51(-/-) Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to...

Topics

Animals
DNA Damage
DNA-Binding Proteins
Drug Resistance, Multiple
Inhibitory Concentration 50
Mutation
Thiadiazoles
Trypanocidal Agents
Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 14506061
DOI: 10.1128/AAC.47.10.3368-3370.2003
PMCID: PMC201145

Genes

RAD51

Provenance

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