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Effects of trypanocidal drugs on DNA synthesis: new insights into melarsoprol growth inhibition

17 Feb 2021

Abstract excerpt

Trypanothione is the primary thiol redox carrier in Trypanosomatids whose biosynthesis and utilization pathways contain unique enzymes that include suitable drug targets against the human parasites in this family. Overexpression of the rate-limiting enzyme, γ-glutamylcysteine synthetase (GSH1), can increase the intracellular concentration of trypanothione. Melarsoprol directly inhibits trypanothione and has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33593467
DOI: 10.1017/s0031182021000317

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