Article

Influence of MUC1 on trafficking of TRPV5 and TRPV6 and <i>in vivo</i> Ca <sup>2+</sup> homeostasis

2022-10-22

Abstract excerpt

<h4>SUMMARY</h4> Polymorphism of the gene encoding mucin 1 ( MUC1 ) is associated with skeletal and dental phenotypes in human genomic studies. Animals lacking MUC1 exhibit mild reduction in bone density. These phenotypes could be a consequence of modulation of bodily Ca homeostasis by MUC1, as suggested by the previous observation that MUC1 enhances cell surface expression of the Ca 2+ -selective channel, TRPV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97e81f88-e17c-56c4-843d-b8d311f2c551
DOI: 10.1101/2022.10.22.513333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influence of MUC1 on trafficking of TRPV5 and TRPV6 and <i>in vivo</i> Ca <sup>2+</sup> homeostasisDOI 10.1101/2022.10.22.513333Read

Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis.Semantic proximity Read

TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.Semantic proximity Read

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.Semantic proximity Read

Trpv5/6 is vital for epithelial calcium uptake and bone formation.Semantic proximity Read

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.Semantic proximity Read

The intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II.Semantic proximity Read

80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).Semantic proximity Read

Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.Semantic proximity Read

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane.Semantic proximity Read

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.Semantic proximity Read

TRPV5 gene polymorphisms in renal hypercalciuria.Semantic proximity Read

The amino-terminal domain of TRPV4 channel is involved in its trafficking to the nucleus.Semantic proximity Read