Article
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.
The Journal of clinical investigation - 1 Dec 2003
Hoenderop Joost G J, van Leeuwen Johannes P T M, van der Eerden Bram C J, Kersten Ferry F J, van der Kemp Annemiete W C M, Mérillat Anne-Marie, Waarsing Jan H, Rossier Bernard C, Vallon Volker, Hummler Edith, Bindels René J M
Abstract excerpt
Ca2+ ions play a fundamental role in many cellular processes, and the extracellular concentration of Ca2+ is kept under strict control to allow the proper physiological functions to take place. The kidney, small intestine, and bone determine the Ca2+ flux to the extracellular Ca2+ pool in a concerted fashion. Transient receptor potential (TRP) cation channel subfamily V, members 5 and 6 (TRPV5 and TRPV6) have...
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