Article
Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis.
The Journal of biological chemistry - 1 Mar 2023
Al-Bataineh Mohammad M, Kinlough Carol L, Marciszyn Allison, Lam Tracey, Ye Lorena, Kidd Kendrah, Maggiore Joseph C, Poland Paul A, Kmoch Stanislav, Bleyer Anthony, Bain Daniel J, Montalbetti Nicolas, Kleyman Thomas R, Hughey Rebecca P, Ray Evan C
Abstract excerpt
Polymorphism of the gene encoding mucin 1 (MUC1) is associated with skeletal and dental phenotypes in human genomic studies. Animals lacking MUC1 exhibit mild reduction in bone density. These phenotypes could be a consequence of modulation of bodily Ca homeostasis by MUC1, as suggested by the previous observation that MUC1 enhances cell surface expression of the Ca2+-selective channel, TRPV5, in cultured...
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