Article

Multiple acyl-CoA dehydrogenase deficiency kills <i>Mycobacterium tuberculosis</i> in vitro and during infection

2021-04-19

Abstract excerpt

<h4>ABSTRACT</h4> The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid β-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitubercular drugs targeting this metabolic pathway. Here, we identify rv0338c , referred to as etfD M...

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Literature Corpus work: 97e64315-7c26-5c2c-94ae-fa474cf6035a
DOI: 10.1101/2021.04.19.440201

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