Article

Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora

2021-06-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that...

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Literature Corpus work: c40425ce-0d97-5878-a43d-5f6333caf6e4
DOI: 10.1101/2021.06.03.446965

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