Article

Genome-wide association study identifies<i>APOE</i>and<i>ZMIZ1</i>variants as mitophagy modifiers in Lewy body disease

2023-10-16

Abstract excerpt

The PINK1-PRKN pathway mediates a critical quality control to maintain mitochondrial health and function. Together the kinase-ligase pair identifies and decorate damaged mitochondria with phosphorylated ubiquitin (p-S65-Ub). This selective label serves as the mitophagy tag and facilitates their degradation via autophagy-lysosome system. While complete loss of PINK1 or PRKN function causes early-onset Parkinson dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db538533-2936-5ecf-9e24-0cb443641830
DOI: 10.1101/2023.10.16.23297100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study identifies<i>APOE</i>and<i>ZMIZ1</i>variants as mitophagy modifiers in Lewy body diseaseDOI 10.1101/2023.10.16.23297100Read

Genome-wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease.Semantic proximity Read

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.Semantic proximity Read

A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's DiseaseSemantic proximity Read

Systematic Functional Analysis of PINK1 and PRKN Coding VariantsSemantic proximity Read

Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonismSemantic proximity Read

Mechanisms Associated with PINK1 Variants in Parkinson's DiseaseSemantic proximity Read

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation.Semantic proximity Read

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependentSemantic proximity Read

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress responseSemantic proximity Read

Distinctive autophagy/mitophagy biomarker profiles in frontotemporal lobar degeneration and Alzheimer’s diseaseSemantic proximity Read

Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes NeurodegenerationSemantic proximity Read

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity Read