Article

Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs

2023-01-31

Abstract excerpt

Physical interactions between T cell receptors (TCRs) and mutation-derived tumour neoantigens (neoAg) presented by major histocompatibility class-I (MHC-I) enable sensitive and specific cytolysis of tumour cells. Adoptive transfer of neoAg-reactive T cells in patients is correlated with response to immunotherapy; however, the structural and cellular mechanisms of neoAg recognition remain poorly understood. We have...

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Literature Corpus work: 97db0034-cae8-5dda-a643-3a333cc3b229
DOI: 10.21203/rs.3.rs-2531184/v1

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