Article
Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope.
Nature communications - 5 Nov 2021
Ebrahimi-Nik Hakimeh, Moussa Marmar, Englander Ryan P, Singhaviranon Summit, Michaux Justine, Pak HuiSong, Miyadera Hiroko, Corwin William L, Keller Grant L J, Hagymasi Adam T, Shcheglova Tatiana V, Coukos George, Baker Brian M, Mandoiu Ion I, Bassani-Sternberg Michal, Srivastava Pramod K
Abstract excerpt
High-affinity MHC I-peptide interactions are considered essential for immunogenicity. However, some neo-epitopes with low affinity for MHC I have been reported to elicit CD8 T cell dependent tumor rejection in immunization-challenge studies. Here we show in a mouse model that a neo-epitope that poorly binds to MHC I is able to enhance the immunogenicity of a tumor in the absence of immunization. Fibrosarcoma...
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