Article

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

2021-02-02

Abstract excerpt

Neoantigens derived from somatic mutations have been demonstrated to correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of personalized medicine approaches although their quality and associated immune responses is not yet well understood. In a case study of metastatic malignant melanoma, we performed...

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Literature Corpus work: aec11435-ab29-5f47-8fa9-cad9575fcea9
DOI: 10.1101/2021.02.02.428777

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