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Article

Structural basis for self-discrimination by neoantigen-specific TCRs.

Nature communications - 8 Mar 2024

Finnigan John P, Newman Jenna H, Patskovsky Yury, Patskovska Larysa, Ishizuka Andrew S, Lynn Geoffrey M, Seder Robert A, Krogsgaard Michelle, Bhardwaj Nina

Abstract excerpt

T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of neoAg from somatic mutations is a major focus of current research. However, the structural and cellular determinants controlling TCR recognition of neoAgs remain poorly...

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Identifiers

PMID: 38459027
DOI: 10.1038/s41467-024-46367-9
PMCID: PMC10924104

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