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Article

Structural basis for oligoclonal T cell recognition of a shared NRAS cancer neoantigen.

Structure (London, England : 1993) - 3 Sept 2026

Sharma Vijay Kumar, Gallagher D Travis, Saravanakumar Shayana, Singh Pragya, Pierce Brian G, Mariuzza Roy A

Abstract excerpt

T cell receptors (TCRs) specific for cancer neoantigens are important for anti-tumor immunity and immunotherapy. To understand the structural basis for T cell recognition of cancer neoantigens, we studied oligoclonal TCRs from patients with melanoma that recognize a neoepitope arising from a driver mutation in NRAS (NRASQ61K) presented by HLA-A1. Structures of these TCRs in unbound form and bound to...

Read the complete abstract on PubMed

Topics

Humans
Membrane Proteins
Antigens, Neoplasm
Receptors, Antigen, T-Cell
GTP Phosphohydrolases
T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Melanoma

Protein Binding

Models, Molecular

Mutation

Crystallography, X-Ray

Source

Identifiers

PMID: 42476141
DOI: 10.1016/j.str.2026.06.008

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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