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Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens

2024-05-23

Abstract excerpt

T cell receptors (TCRs) that recognize cancer neoantigens are important for anti-cancer immune responses and immunotherapy. Understanding the structural basis of TCR recognition of neoantigens provides insights into their exquisite specificity and can enable design of optimized TCRs. We determined crystal structures of a human TCR in complex with NRAS Q61K and Q61R neoantigen peptides and HLA-A1 MHC, revealing the...

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Literature Corpus work
d9a81b10-e98f-532b-b4b4-52a2183beb2a
DOI
10.1101/2024.05.21.595215
Open publication

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Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigensDOI 10.1101/2024.05.21.595215
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