Article
Neoantigen landscape dynamics during human melanoma-T cell interactions.
Nature - 4 Aug 2016
Verdegaal Els M E, de Miranda Noel F C C, Visser Marten, Harryvan Tom, van Buuren Marit M, Andersen Rikke S, Hadrup Sine R, van der Minne Caroline E, Schotte Remko, Spits Hergen, Haanen John B A G, Kapiteijn Ellen H W, Schumacher Ton N, van der Burg Sjoerd H
Abstract excerpt
Recognition of neoantigens that are formed as a consequence of DNA damage is likely to form a major driving force behind the clinical activity of cancer immunotherapies such as T-cell checkpoint blockade and adoptive T-cell therapy. Therefore, strategies to selectively enhance T-cell reactivity against genetically defined neoantigens are currently under development. In mouse models, T-cell pressure can sculpt the...
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