Article

Distinct sets of molecular characteristics define tumor-rejecting neoantigens

2024-02-16

Abstract excerpt

Challenges in identifying tumor-rejecting neoantigens limit the efficacy of neoantigen vaccines to treat cancers, including cutaneous squamous cell carcinoma (cSCC). A minority of human cSCC tumors shared neoantigens, supporting the need for personalized vaccines. Using a UV-induced mouse cSCC model which recapitulated the mutational signature and driver mutations found in human disease, we found that CD8 T cells...

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Literature Corpus work: dd69caf2-134c-51c3-9cce-fc6ed439c578
DOI: 10.1101/2024.02.13.579546

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