Article

Signaling input from divergent pathways subverts malignant B-cell transformation

2020-03-14

Abstract excerpt

Malignant transformation typically involves multiple genetic lesions whose combined activity gives rise to cancer 1 . Our analysis of 1,148 patient-derived B-cell leukemia (B-ALL) samples revealed that individual mutations did not promote leukemogenesis unless they converged on one single oncogenic pathway characteristic for the differentiation status of these transformed B cells. Specifically, we show here the J...

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Literature Corpus work: 37c61184-ab7b-5d18-a25b-13e387c0607c
DOI: 10.1101/2020.03.12.989749

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