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Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions

15 Apr 2025

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and pathological brain changes. While aging is the primary risk factor, circadian rhythm disruption (CRD) is increasingly recognized as a central driver of AD pathology. CRD exacerbates oxidative stress, systemic inflammation, and gut microbiome dysbiosis, impairing sleep-wake cycles, disrupting metabolic...

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PMID: 40654342
DOI: 10.1016/j.apsb.2025.04.011

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