Article

Force transmission balance through adhesions determines multicellular handedness

2026-04-07

Abstract excerpt

Cell chirality has been implicated in left-right (LR) asymmetric morphogenesis, yet multicellular handedness is not a simple readout of single-cell chirality. Here, we show that multicellular LR asymmetry is determined by the balance of force transmission through cell-cell and cell-substrate adhesions. Combining experiments in human epithelial cells with theoretical modeling, we demonstrate that clockwise-rotating...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97ca52e4-e1cd-5c97-a615-712184e766e2
DOI: 10.64898/2026.04.04.716462

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Force transmission balance through adhesions determines multicellular handednessDOI 10.64898/2026.04.04.716462Read

Left-right asymmetry is formed in individual cells by intrinsic cell chirality.Semantic proximity Read

Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry.Semantic proximity Read

Robust axis formation requires both short-range adhesion and long-range attractionSemantic proximity Read

Anisotropic Cellular Forces Drive Hexagonal-to-Tetragonal Tiling Transitions in the Drosophila Eye.Semantic proximity Read

Sticky business: orchestrating cellular signals at adherens junctions.Semantic proximity Read

Rules of Contact Inhibition of Locomotion for Cells on Suspended NanofibersSemantic proximity Read

Long range mutual activation establishes Rho and Rac polarity during cell migrationSemantic proximity Read

Torques within and outside the human spindle balance twist at anaphaseSemantic proximity Read

From cytoskeletal dynamics to organ asymmetry: a non-linear, regulative pathway underlies left-right patterningSemantic proximity Read

“Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration”Semantic proximity Read

Left-right asymmetry: actin-myosin through the looking glass.Semantic proximity Read

The mechanical cell – the role of force dependencies in synchronising protein interaction networksSemantic proximity Read