Article
Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011
Wan Leo Q, Ronaldson Kacey, Park Miri, Taylor Grace, Zhang Yue, Gimble Jeffrey M, Vunjak-Novakovic Gordana
Abstract excerpt
Left-right (LR) asymmetry (handedness, chirality) is a well-conserved biological property of critical importance to normal development. Changes in orientation of the LR axis due to genetic or environmental factors can lead to malformations and disease. While the LR asymmetry of organs and whole organisms has been extensively studied, little is known about the LR asymmetry at cellular and multicellular levels....
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