From cytoskeletal dynamics to organ asymmetry: a non-linear, regulative pathway underlies left-right patterning

Abstract excerpt

Consistent left-right asymmetry is a fundamental aspect of the bodyplan across phyla, and errors of laterality form an important class of human birth defects. Its molecular underpinning was first discovered as a sequential pathway of left-and right-sided gene expression that controlled positioning of the heart and visceral organs. Recent data have revised this picture in two important ways. First, the physical ori...

Topics

Open a Topic to create a Post that cites this publication.

• Body Patterning
• Chick Embryo
• Embryo, Mammalian
• Embryo, Nonmammalian
• Gene Expression Regulation, Developmental
• Mice
• Models, Biological
• Mutation

Identifiers and source

Literature Corpus work

85ad5ba1-378c-5874-85f1-610245d19634

DOI

10.1101/052191