Article

Robust axis formation requires both short-range adhesion and long-range attraction

2025-09-29

Abstract excerpt

<h4>SUMMARY</h4> Establishing the anterior-posterior (A-P) axis is a key symmetry-breaking event in mammalian development. Gastruloids, aggregates of embryonic stem cells, undergo a similar process, forming a single posterior pole from an initially spherical aggregate. This requires the aggregate to convert an inside-outside difference in cell state into one A-P axis. We asked what cell-cell interactions can make...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b8fbdaa-4846-52ab-abc0-c68bfe528ddb
DOI: 10.1101/2025.09.27.678924

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust axis formation requires both short-range adhesion and long-range attractionDOI 10.1101/2025.09.27.678924Read

Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongationSemantic proximity Read

Sticky business: orchestrating cellular signals at adherens junctions.Semantic proximity Read

Force transmission balance through adhesions determines multicellular handednessSemantic proximity Read

Molecular mechanism of symmetry breaking in a 3D model of a human epiblastSemantic proximity Read

BMP4-induced symmetry breaking in a 3D model of the human epiblastSemantic proximity Read

Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns: Commitment of cell specification is constrained by physical cues.Semantic proximity Read

Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongationSemantic proximity Read

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation.Semantic proximity Read

Boundary constraints can determine pattern emergenceSemantic proximity Read

Rules of Contact Inhibition of Locomotion for Cells on Suspended NanofibersSemantic proximity Read

Mechanics regulate human embryonic stem cell self-organization to specify mesodermSemantic proximity Read

Symmetry breaking of hPSCs in micropattern generates a polarized spinal cord-like organoid (pSCO) with dorsoventral organizationSemantic proximity Read