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The complex development of psoralen-interstrand crosslink resistance in <i>Escherichia coli</i> requires AcrR inactivation, retention of a <i>marbox</i> sequence, and one of three MarA, SoxS, or Rob global regulators

2024-12-07

Abstract excerpt

Crosslinking agents, such as psoralen and UVA radiation, can be effectively used as antimicrobials and for treating several dysplastic conditions in humans, including some cancers. Yet, both cancer cells and bacteria can become resistant to these compounds, making it important to understand how resistance develops. Recently, several mutants were isolated that developed high-levels of resistance to these compounds...

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Literature Corpus work
97bc640c-50e2-515a-8ad9-a0ab03c01356
DOI
10.1101/2024.12.03.626702
Open publication

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The complex development of psoralen-interstrand crosslink resistance in <i>Escherichia coli</i> requires AcrR inactivation, retention of a <i>marbox</i> sequence, and one of three MarA, SoxS, or Rob global regulatorsDOI 10.1101/2024.12.03.626702
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