Article

Bicyclomycin generates ROS and blocks cell division in <i>Escherichia coli</i>

2023-10-24

Abstract excerpt

The role of reactive oxygen species (ROS) in the killing exerted by antibiotics on bacteria is debated. Evidences attribute the part of toxicity of many antibiotics to their ability to generate ROS by interfering with cellular metabolism, but some studies dismiss the role of ROS. Bicyclomycin (BCM) is a broad-spectrum antibiotic that is the only known compound to inhibit E. coli transcription terminator factor Rh...

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Literature Corpus work: 90457d9e-702d-52e2-ba59-667f3a3ec603
DOI: 10.1101/2023.10.23.563548

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