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Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical <i>Escherichia coli</i> Strains from China: Role of <i>acrR</i> Mutations

1 May 2001

Abstract excerpt

The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated resistance to a variety of other antibiotics. PCR sequence analysis of the quinolone resistance-determining region of the topoisomerase genes (gyrA/B, parC) revealed three to five mutations known to be associated with...

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PMID: 11302820
DOI: 10.1128/aac.45.5.1515-1521.2001

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