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Article

Molecular basis of antibiotic multiresistance transfer in <i>Staphylococcus aureus</i>

28 Jan 2013

Abstract excerpt

Multidrug-resistant Staphylococcus aureus infections pose a significant threat to human health. Antibiotic resistance is most commonly propagated by conjugative plasmids like pLW1043, the first vancomycin-resistant S. aureus vector identified in humans. We present the molecular basis for resistance transmission by the nicking enzyme in S. aureus (NES), which is essential for conjugative transfer. NES initiates...

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PMID: 23359708
DOI: 10.1073/pnas.1219701110

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