Article

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep

2026-04-09

Abstract excerpt

<h4>Summary</h4> Excessive daytime sleepiness (EDS) is a heterogeneous phenotype with little known of its genetic basis. Large-scale genome-wide association studies (GWAS) have reported genomic loci associated with EDS, though since most of these are non-coding, the causal gene(s) underlying the association are not known. Additionally, the cell types in which these genes exert their effects on sleep have not been...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97ade04d-5a68-5580-b417-9f09f6ba2fd2
DOI: 10.64898/2026.04.07.715910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleepDOI 10.64898/2026.04.07.715910Read

Cross-species variant-to-function analyses implicate <i>MEIS1</i> in conferring sleep abnormalities and impaired cerebellar developmentSemantic proximity Read

Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleepSemantic proximity Read

Zebrafish screen of high-confidence effector genes at insomnia GWAS loci implicates conserved regulators of sleep-wake behaviorsSemantic proximity Read

Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.Semantic proximity Read

Genetics of Sleepwalking: Insights from whole exome sequencingSemantic proximity Read

Perturbation of the insomnia <i>WDR90</i> GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, <i>PIG-Q</i>Semantic proximity Read

A patient-derived mouse model reproduces molecular, neurological, and sleep symptoms of SHINE syndrome.Semantic proximity Read

Shank3 Modulates Sleep and Expression of Circadian Transcription FactorsSemantic proximity Read

Multiple genes <i>in cis</i> mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neuronsSemantic proximity Read

Recent advances in understanding the genetics of sleepSemantic proximity Read

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effectsSemantic proximity Read

Shank3 modulates sleep and expression of circadian transcription factorsSemantic proximity Read