Article
Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
Sleep - 11 Jul 2024
Sonti Shilpa, Littleton Sheridan H, Pahl Matthew C, Zimmerman Amber J, Chesi Alessandra, Palermo Justin, Lasconi Chiara, Brown Elizabeth B, Pippin James A, Wells Andrew D, Doldur-Balli Fusun, Pack Allan I, Gehrman Phillip R, Keene Alex C, Grant Struan F A
Abstract excerpt
Although genome-wide association studies (GWAS) have identified loci for sleep-related traits, they do not directly uncover the underlying causal variants and corresponding effector genes. The majority of such variants reside in non-coding regions and are therefore presumed to impact cis-regulatory elements. Our previously reported 'variant-to-gene mapping' effort in human induced pluripotent stem cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.