Article

Zebrafish screen of high-confidence effector genes at insomnia GWAS loci implicates conserved regulators of sleep-wake behaviors

2022-10-07

Abstract excerpt

Recent large-scale human genome-wide association studies (GWAS) for insomnia have identified more than 200 significant loci. The functional relevance of these loci to the pathogenesis of insomnia is largely unknown. GWAS signals are typically non-coding variants, which are often arbitrarily annotated to the nearest protein-coding gene; however, due to 3D chromatin structure, variants can interact with more distal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14a64412-68e4-5928-8b77-13a8df13519a
DOI: 10.1101/2022.10.05.511011

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Zebrafish screen of high-confidence effector genes at insomnia GWAS loci implicates conserved regulators of sleep-wake behaviorsDOI 10.1101/2022.10.05.511011Read

Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar developmentSemantic proximity Read

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleepSemantic proximity Read

Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.Semantic proximity Read

Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-QSemantic proximity Read

Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitabilitySemantic proximity Read

Shank3 modulates sleep and expression of circadian transcription factorsSemantic proximity Read

Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating SleepSemantic proximity Read

Integrative genomics analysis identifies five promising genes implicated in insomnia risk based on multiple omics datasets.Semantic proximity Read

Shank3 Modulates Sleep and Expression of Circadian Transcription FactorsSemantic proximity Read

Drosophila Modeling of Insomnia-Associated Genes Reveals Diverse Underlying Sleep PhenotypesSemantic proximity Read

Sleep disturbances associated with DEAF1 pathogenic variants.Semantic proximity Read

Recent advances in understanding the genetics of sleepSemantic proximity Read