Article

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

2021-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies. RBD also defines more severe forms of alpha-synucleinopathies. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we performed the first genome-wide association study of RBD, identifying five RBD risk loci. E...

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Literature Corpus work: 83abc1f5-ec29-5f59-8e79-7856c7f5040a
DOI: 10.1101/2021.09.08.21254232

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